Leaders of some EU member countries and EU finance leaders have commented on the result. Many say it's a domestic matter, and won't have much impact on the EU and Eurozone.

"I am sad that the referendum in Italy did not turn out as the prime minister wished because I always supported his reform policies but it is of course a domestic Italian decision that we must respect," said Angela Merkel.

"There is no particular systematic risk and, above all, decisions about a constitutional issue in Italy could in no way create a systematic risk," said Michel Sapin, French Finance Minister.

"We took note of the outcome and it's of course up to the Italian president now to take further decisions on the democratic process because this is what it is; it's a democratic process," said Jeroen Dijsselbloem, Eurogroup Chairman.

"It doesn’t really change the situation economically in Italy or in the Italian banks; the problems that we have today are the problems that we had yesterday and they still have to be dealt with and that process will continue as far as I am concerned so let's wait for the outcome of the political process. Italy is one of the most resilient economy in Eurozone."